Correlative Microscopy: A Potent Tool for Biomedicine

3D Correlative Light and Scanning Electron Microscopy: a New Tool for Systems Biology

Modern Cell Biology, Biochemistry, and Neuroscience are dealing with large numbers of proteins (1.5x10 proteins/cell), lipids and their biophysical and biochemical properties in single cells or thousands of cells in their natural tissue context. In current systems biology experiments several thousands of proteins and their potential network can be identified. By contrast, state of the art light...

Registration for Correlative Microscopy Using Image Analogies

Abstract. Correlative microscopy is a methodology combining the functionality of light microscopy with the high resolution of electron microscopy and other microscopy technologies for the same biological specimen. In this paper, we propose an image registration method for correlative microscopy, which is challenging due to the distinct appearance of biological structures when imaged with di↵ere...

Multi-modal Image Registration for Correlative Microscopy

Correlative microscopy is a methodology combining the functionality of light microscopy with the high resolution of electron microscopy and other microscopy technologies. Image registration for correlative microscopy is quite challenging because it is a multi-modal, multi-scale and multi-dimensional registration problem. In this report, I introduce two methods of image registration for correlat...

Hypergravity As a Tool for Cell Stimulation: Implications in Biomedicine

Gravity deeply influences numerous biological events in living organisms. Variations in gravity values induce adaptive reactions that have been shown to play important roles, for instance in cell survival, growth, and spatial organization. In this paper, we summarize effects of gravity values higher than that one experienced by cells and tissues on Earth, i.e., hypergravity, with particular att...

microscopy and analysis Correlative Light and Electron Microscopy